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Dissertation on antimicrobial peptides

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Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password. Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan. Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires. Hitesh Thaker , University of Massachusetts - Amherst. The rise in bacterial resistance and the declining approval rate of novel anti-infective drugs are a major threat to global public health.
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Novel Host Defence Peptide Prodrugs for use in Cystic Fibrosis

Dissertation on antimicrobial peptides
Dissertation on antimicrobial peptides
Dissertation on antimicrobial peptides
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Antimicrobial Peptides: Mechanisms of Action and Resistance

Include Synonyms Include Dead terms. Direct link. Dissertation, University of Illinois at Urbana-Champaign. Lantibiotics are bacterial-derived polycyclic antimicrobial peptides. They are genetically encoded and ribosomally synthesized as precursor peptides containing a structural region that undergoes post-translational modification and a leader sequence that is not modified. Specific serine and threonine residues in the pre-lantibiotic structural region are dehydrated to dehydroalanine Dha and dehydrobutyrine Dhb , respectively, and subsequently cyclized through intramolecular addition of cysteine thiol groups to these unsaturated amino acids. This process results in the formation of lanthionine Lan; from Dha and methyllanthionine MeLan; from Dhb rings.
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Synthetic mimics of antimicrobial peptides from aryl scaffolds

In the latest report from the Centers for Disease Control and Prevention CDC on antimicrobial resistance, this problem remains to be an urgent global threat, infecting about three million people and killing about 36, people in the United States annually. Antimicrobial peptides AMPs offer a number of advantages over small molecule antibiotics, such as their structural flexibility in response to different local environments, allowing for having environment-responsive modes of action. Experimentally, it was shown that ClavA acts via different mechanisms at different pHs, pointing to a more membrane-active mechanism at pH 7 than at pH 5.
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The misuse and abuse of antibiotics have given rise to a severe problem of the drug resistance of bacteria. Solving this problem has been a vitally important task in the modern medical arena. On the one hand, BF2b has unique anti-bacterial performance and has a lower tendency than traditional antibiotics to engender the drug resistance of bacteria. On the other hand, AuNRs have diverse distinct properties, such as photo-thermal conversion, which can be employed for photo-thermal sterilization. We aimed to integrate the anti-bacterial activity of BF2b and the photo-thermal sterilization of AuNRs to kill drug-resistant bacteria.
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