Abstract Clostridium difficile Infection CDI is a major cause of hospital-acquired diarrhea and is most commonly associated with changes in normal intestinal flora caused by administration of antibiotics. The recent emergence of strains of C. Few studies have examined increases in the risk of CDI associated with total cumulative dose, duration, or number of antibiotics. Therefore, a retrospective cohort study was conducted to determine the incidence of CDI at Strong Memorial Hospital in among hospitalizations during which two or more consecutive days of antibiotics were prescribed, and to examine the class, total dose measured in Defined Daily Doses DDD , days, and number of antibiotics in relation to CDI. Dose-response relationships were observed, with increasing exposure conferring increasing CDI risk for all dose-related antibiotic measures evaluated.
C. difficile infection - Symptoms and causes - Mayo Clinic
Rangachar Srinivasa, Vatsala Clostridium difficile infection spread within the hospital environment. Master's Thesis, University of Pittsburgh. Background: Clostridium difficile Infection CDI is one of the leading causes of hospital-associated infections HAIs and accounts for nearly half a million infections in the United States It was associated with approximately 29, deaths nationwide in This study focusses on the role of the environment in the spread of CDI within a hospital in a non-outbreak setting. Statement of public health significance: The Centers for Disease Control and Prevention CDC classifies CDI threat rate as five, which requires urgent and aggressive public health action, because CDI is associated with significant morbidity and mortality.
Factors affecting the detection of Clostridium difficile in faecal samples
Understanding risk perceptions and responses of the public, healthcare professionals and the media. Emma Jane Burnett. Abstract My original contribution to knowledge is the emergence of an inductively derived conceptual framework that provides a generic account of the way in which people construct and communicate risk. Within this framework, a detailed contextual understanding of how this was applied to C. Furthermore, in seeking to place responses to health risks in the wider social, cultural and political context, moving beyond a standard critique of media output, an understanding of both how and why the media report health-related risks helped identify ways in which the media can influence how people can construct and communicate about risks.
Nazari Shirvan, Ali Molecular analysis of surface proteins of Clostridium difficile. PhD thesis, University of Glasgow. Since the Gram positive anaerobe Clostridium difficile was first isolated and described, it has emerged as an increasingly important nosocomial pathogen in Europe, North America and elsewhere, and the prime causative agent of antibiotic associated dirrhoea and pseudomembranous colitis in humans.